Ticagrelor Impurities

General Information

Ticagrelor Impurities and Ticagrelor

Daicel Pharma is a reliable source for synthesizing high-quality Ticagrelor impurities like (1S,2S,3R,5S)-3-((5-amino-2-(propylthio)pyrimidin-4-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol,2-(2,3-difluorophenyl)cyclopropanamine hydrochloride, 2-(3,5-difluorophenyl)cyclopropanamine hydrochloride, O-acetyl Ticagrelor, Ticagrelor acetonide, Ticagrelor amine impurity AR-C133913XX and many more. These impurities are essential in accurately analyzing the Ticagrelor quality, stability, and biological safety. Additionally, Daicel Pharma offers a customized synthesis of Ticagrelor impurities for global delivery to meet the specific needs of our customers.

Ticagrelor [CAS: 274693-27-5] is a P2Y12 receptor antagonist. It lowers the likelihood of myocardial infarction and ischemic stroke.

Ticagrelor: Use and Commercial Availability

Ticagrelor lowers the risk of myocardial infarction and ischemic stroke by inhibiting thrombus formation. This medication reduces the risk of cardiovascular death, myocardial infarction, and stroke in individuals with acute coronary syndrome or a history of myocardial infarction.

Ticagrelor is available under Brilinta, which contains the active ingredient, Ticagrelor.

Ticagrelor Structure and Mechanism of Action

The chemical name of Ticagrelor is (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol. Its chemical formula is C₂₃H₂₈F₂N₆O₄S, and its molecular weight is approximately 522.6 g/mol.

Ticagrelor prevents signal transduction and platelet activation by reversibly interacting with the platelet P2Y12 ADP receptor.

Ticagrelor Impurities and Synthesis

During Ticagrelor manufacturing¹, impurity formation is possible, compromising its effectiveness. They can arise from various sources, including the raw materials, intermediates, and chemicals utilized to synthesize Ticagrelor. To ensure the drug’s optimal efficacy and safety, closely managing and monitoring these impurities is paramount.

Daicel offers a wholesome and integrated Certificate of Analysis (CoA) for Ticagrelor impurity standards, encompassing(1S,2S,3R,5S)-3-((5-amino-2-(propylthio)pyrimidin-4-yl)amino)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, 2-(2,3-difluorophenyl)cyclopropanamine hydrochloride, 2-(3,5-difluorophenyl)cyclopropanamine hydrochloride, O-acetyl Ticagrelor, Ticagrelor acetonide, Ticagrelor amine impurity AR-C133913XX and many more. The Certificate of Analysis (CoA) offers detailed characterization data, including 1H NMR, 13C NMR, IR, MASS, and HPLC purity², ensuring comprehensive information about the product. Furthermore, Daicel Pharma possesses advanced technological capabilities and expertise to synthesize any unknown impurities or degradation products of Ticagrelor.