Remdesivir Impurities

General Information

Remdesivir Impurities and Remdesivir  

Daicel Pharma offers high-quality Remdesivir impurity standards, (R)-Tri O-benzyl nitrile Impurity, N-Butyl (SRR) Remdesivir, RDV pentafluoro RR isomer, Remdesivir Impurity- 1, Remdesivir Impurity 8, Remdesivir Impurity C, Remdesivir Impurity- 18, Remdesivir Impurity 14, Remdesivir R-P D-Alanine isomer, Remdesivir- S-Isomer at CN, and more. The effectiveness, stability, safety, and quality analysis of Remdesivir depends on these impurities. Daicel Pharma offers custom synthesis for Remdesivir impurities and delivers them internationally.

Remdesivir [CAS: 1809249-37-3] is an antiviral medication for treating RNA virus infections. It is a SARS-CoV-2 nucleotide analog RNA polymerase inhibitor.

Remdesivir: Use and Commercial Availability 

Remdesivir treats mild-to-moderate COVID-19 patients at high risk of severe COVID-19, including hospitalization or death.

This medication is available under the brand name Veklury.

Remdesivir Structure and Mechanism of Action

The chemical name of Remdesivir is (S)-2-Ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate. Its chemical formula is C₂₇H₃₅N₆O₈P, and its molecular weight is approximately 602.6 g/mol.

Remdesivir inhibits the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and blocks viral RNA synthesis.

Remdesivir Impurities and Synthesis

Remdesivir impurities are unintended chemical compounds present during the synthesis¹ or storage of Remdesivir, an antiviral medication for treating viral infections such as COVID-19. These impurities can arise from various sources, including starting materials, reagents, intermediates, or degradation products.

Daicel Pharma offers a Certificate of Analysis (CoA) for Remdesivir impurity standards that involve (R)-Tri O-benzyl nitrile Impurity, N-Butyl (SRR) Remdesivir, RDV pentafluoro RR isomer, Remdesivir Impurity- 1, Remdesivir Impurity 8, Remdesivir Impurity C, Remdesivir Impurity- 18, Remdesivir Impurity 14, Remdesivir R-P D-Alanine isomer, Remdesivir- S-Isomer at CN, and more. Our cGMP-certified analytical laboratory provides CoA with detailed characterization data such as 1H NMR, 13C NMR, IR, MASS, and HPLC purity². More characterization details, such as those for 13C-DEPT, can be provided on request. Daicel Pharma specializes in synthesizing Remdesivir impurities and degradation products.